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June 13, 2024
Original Investigation

Circulating Tumor DNA-Guided De-Escalation Targeted Therapy for Advanced Non鈭扴mall Cell Lung Cancer: A Nonrandomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1779

This nonrandomized clinical trial assesses the feasibility of using a circulating tumor DNA鈭抔uided adaptive de-escalation tyrosine kinase inhibitor strategy in patients with advanced non鈭抯mall cell lung cancer to achieve complete remission after local consolidative therapy.

Stereotactic Ablative Radiotherapy for Gynecological Oligometastatic and Oligoprogessive Tumors

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1796

This cohort study evaluates the outcomes of stereotactic ablative radiotherapy in patients with oligometastatic and oligoprogressive gynecologic cancers.

Home Time Among Older Adults With Acute Myeloid Leukemia Following Chemotherapy

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1823

This retrospective cohort study quantifies and compares home time for older patients with newly diagnosed acute myeloid leukemia receiving either hypomethylating agents or anthracycline-based chemotherapy.

Viewpoint

Sexual Rehabilitation Needs of Gay and Bisexual Men With Cancer

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1586

This Viewpoint discusses the importance of concentrating research efforts and clinical training on sexual and gender minority individuals who survive cancer, particularly on sexual rehabilitation.

Comment & Response

Valid Analysis of Brain-Specific Progression-Free Survival

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1693

Valid Analysis of Brain-Specific Progression-Free Survival

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1696

Valid Analysis of Brain-Specific Progression-Free Survival鈥擱eply

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1699
June 6, 2024
Original Investigation

Comprehensive Audiologic Analyses After Cisplatin-Based Chemotherapy

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1233

This cohort study evaluates cisplatin-related hearing loss with comprehensive audiologic assessments, assesses the longitudinal progression of cisplatin-related hearing loss, and identifies factors associated with risk.

Cardiovascular Events and Androgen Receptor Signaling Inhibitors in Advanced Prostate Cancer: A Systematic Review and Meta-Analysis

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1549

This systematic review and meta-analysis investigates the incidence of cardiovascular events with addition of novel androgen receptor signaling inhibitors (ARSI) to standard of care in locally advanced and metastatic prostate cancer.

Neoadjuvant Nivolumab Plus Chemotherapy Followed By Response-Adaptive Therapy for HPV+ Oropharyngeal Cancer: OPTIMA II Phase 2 Open-Label Nonrandomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1530

This phase 2 nonrandomized clinical trial evaluates effectiveness and tolerance of neoadjuvant nivolumab, nab-paclitaxel, and carboplatin followed by response-adaptive therapy in patients with human papillomavirus鈭抪ositive oropharyngeal cancer.

JAMA Oncology Clinical Challenge

Lymphoma With a Skin Rash

Abstract Full Text
has active quiz
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1558

A 62-year-old female had a generalized vesiculobullous rash on her face for 4 months. It started over the lips and gradually progressed to involve the oral mucosa and skin of the whole body. What is your diagnosis?

Viewpoint

Radiation With Immunotherapy May Be a Double-Edged Sword鈥擧ow Can We Learn From Recent Negative Clinical Trials?

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1527

This Viewpoint explains differences between recent studies using radiotherapy with immunotherapy and possible reasons for their different outcomes.

Invited Commentary

Cardiovascular Risk in Prostate Cancer鈥擜 Call to Action?

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.0860
Comment & Response

Immunotherapy For US Patients With Metastatic Cancer at the End of Life

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1563

Immunotherapy For US Patients With Metastatic Cancer at the End of Life鈥擱eply

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1566
June 3, 2024
Original Investigation

Assessing the Environmental and Downstream Human Health Impacts of Decentralizing Cancer Care

Abstract Full Text
JAMA Oncol. Published online June 3, 2024. doi:10.1001/jamaoncol.2024.2744

This cohort study assesses potential reductions in greenhouse gas emissions and downstream health harms associated with telemedicine and fully decentralized cancer care.

Research Letter

Geographic Distribution of Clinical Trials for Advanced-Stage Cancer

Abstract Full Text
open access
JAMA Oncol. Published online June 3, 2024. doi:10.1001/jamaoncol.2024.1690

This quality improvement study evaluates the geographic distribution of clinical trials and assesses the distances patients with cancer must travel to access a clinical trial site.

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